SCHEMBL2505145

SCHEMBL2505145

CC(C)Cc1ccc(C(C)C)c(OC(=O)c2ccccc2)c1OC(=O)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
LMNA P02545 3/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 4/20 0.38
TDP1 Q9NUW8 2/20 0.38
MEN1 O00255 1/20 0.38
TSHR P16473 2/20 0.38
ALDH1A1 P00352 3/20 0.37
GABRA1 P14867 1/20 0.37
GABRB1 P18505 1/20 0.37
GLRA1 P23415 1/20 0.36
PKM P14618 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2513082 0.91 LMNA (0.46) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2504098 0.89 LMNA (0.42) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2505285 0.87 LMNA (0.43) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2503264 0.87 TSHR (0.48) MAPTLMNAGAAKMT2ATDP1
SCHEMBL2507665 0.85 LMNA (0.42) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2483019 0.84 LMNA (0.41) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2509841 0.83 LMNA (0.43) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2505489 0.83 LMNA (0.40) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2483204 0.82 PDCD1 (0.40) MAPTLMNAPOLBGAAKMT2A
SCHEMBL2509866 0.81 LMNA (0.41) MAPTLMNAPOLBGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376423-A1 PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS Dow Global Technologies LLC (US) 2011-10-19 EP disclosed
WO-2010078519-A1 PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-07-08 WO disclosed