Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17166457 | 1.00 | TSHR (0.41) | TSHRUSP2CYP2D6CYP2C9HSD17B10 | |
| SCHEMBL25051581 | 1.00 | TSHR (0.41) | TSHRUSP2CYP2D6CYP2C9HSD17B10 | |
| SCHEMBL16565923 | 0.89 | CYP11B1 (0.46) | TSHRUSP2CYP2D6CYP2C9HSD17B10 | |
| SCHEMBL21673246 | 0.81 | SMN1; SMN2 (0.43) | CYP11B1CYP11B2PDCD1LG2CD274OPRM1 | |
| SCHEMBL22047418 | 0.79 | CYP11B1 (0.39) | TSHRUSP2CYP2D6CYP2C9CYP11B1 | |
| SCHEMBL24938398 | 0.79 | CD274 (0.45) | TSHRCYP2D6CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL22047376 | 0.79 | CYP11B1 (0.39) | CYP11B1CYP11B2PDCD1LG2CD274OPRM1 | |
| SCHEMBL17166228 | 0.79 | CYP11B1 (0.39) | CYP11B1CYP11B2PDCD1LG2CD274OPRM1 | |
| SCHEMBL8008730 | 0.78 | CYP11B1 (0.48) | TSHRCYP11B1CYP11B2PDCD1LG2CD274 | |
| SCHEMBL2522078 | 0.75 | OPRM1 (0.47) | CYP11B1CYP11B2PDCD1LG2CD274OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018810-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2023-02-16 | — | — | WO | disclosed |