SCHEMBL25057147

SCHEMBL25057147

COc1ccc2c(C#Cc3c4ccccc4c(C#Cc4cccc5cc(OC)ccc45)c4cc(S)ccc34)cccc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP2A6 P11509 1/20 0.41
DHFR P00374 1/20 0.35
CHAT P28329 1/20 0.35
CYP2D6 P10635 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
CYP2B6 P20813 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19449071 0.91 CYP1A2 (0.49) CYP1A2CYP2A6DHFRCHATCYP2D6
SCHEMBL18239273 0.86 CYP1A2 (0.41) CYP1A2CYP2A6DHFRCHATCYP2D6
SCHEMBL16925648 0.85 CYP1A2 (0.41) CYP1A2CYP2A6DHFRCHATCYP2D6
SCHEMBL19449089 0.83 CYP1A2 (0.39) CYP1A2CYP2A6DHFRCHATCYP2D6
SCHEMBL23169140 0.83 CYP1A2 (0.42) CYP1A2CYP2A6DHFRCHATCYP2D6
SCHEMBL20042831 0.77 ACACB (0.38) CYP1A2CYP2A6CYP2D6MTNR1AMTNR1B
SCHEMBL18251573 0.75 ACACB (0.35) CYP1A2CYP2A6CYP2D6MEN1KMT2A
SCHEMBL18251427 0.74 ACACB (0.34) CYP1A2CYP2A6CYP2D6MTNR1AMTNR1B
SCHEMBL7802786 0.72 CYP1A2 (0.44) CYP1A2CYP2A6DHFRCYP2D6CYP3A4
SCHEMBL28220756 0.72 CYP1A2 (0.44) CYP1A2CYP2A6DHFRCYP2D6KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4137818-A1 USE OF DIVALENT METALS FOR ENHANCEMENT OF FLUORESCENT SIGNALS Sony Group Corporation (JP) 2023-02-22 EP disclosed