Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.54 |
| ▸ | CHKA | P35790 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25058864 | 0.88 | HDAC1 (1.00) | HDAC1HDAC6TNFNOD2NOD1 | |
| SCHEMBL20672151 | 0.86 | TNF (0.64) | HDAC1HDAC6LMNATNFNOD2 | |
| SCHEMBL26159155 | 0.84 | HDAC1 (0.68) | HDAC1HDAC6LMNATNFNOD2 | |
| SCHEMBL25058892 | 0.82 | HDAC1 (0.66) | HDAC1HDAC6ABCC1SMN1; SMN2ABCB1 | |
| SCHEMBL3148037 | 0.81 | HDAC1 (0.65) | HDAC1HDAC6LMNAABCC1SMN1; SMN2 | |
| SCHEMBL7846425 | 0.80 | SIGMAR1 (0.65) | HDAC1HDAC6HRH3 | |
| SCHEMBL16130131 | 0.79 | CHKA (0.60) | ACACBCHKAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL3148683 | 0.78 | HDAC1 (0.61) | HDAC1HDAC6LMNAKDM4EABCC1 | |
| SCHEMBL1263320 | 0.78 | ACACB (0.56) | HDAC1HDAC6TNFNOD2NOD1 | |
| SCHEMBL15327056 | 0.78 | RYR2 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159463-A1 | BENZONITRIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI ZHONGZE THERAPEUTICS, CO. LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230159463-A1 | BENZONITRIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI ZHONGZE THERAPEUTICS, CO. LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| EP-4137483-A1 | BENZONITRIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Zhongze Therapeutics, Co. Ltd. (CN) | 2023-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159463-A1 | BENZONITRIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | HDAC11, HDAC1, HDAC6 | HDAC1 2/4885HDAC6 3/4885LMNA 2388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.