Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.43 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.40 |
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22580839 | 0.83 | FEN1 (0.48) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL25060598 | 0.82 | MAPK1 (0.37) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL18113016 | 0.82 | MAPK1 (0.57) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL25060796 | 0.81 | MAPK1 (0.46) | MAPK1PARP11PARP10FEN1ALOX5AP | |
| SCHEMBL20091533 | 0.80 | MAPK1 (0.59) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL25060612 | 0.78 | MAPK1 (0.55) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL21062744 | 0.78 | MAPK1 (0.49) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL18113019 | 0.77 | MAPK1 (0.52) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL22580810 | 0.77 | MAPK1 (0.50) | MAPK1PARP11PARP10FEN1MAPKAPK2 | |
| SCHEMBL18113022 | 0.76 | MAPK1 (0.55) | MAPK1PARP11PARP10FEN1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724180-B1 | COMPOUNDS FOR THE DEGRADATION OF STK4 AND TREATMENT OF HEMATOLOGIC MALIGNANCIES | DANA FARBER CANCER INST INC (US) | 2023-02-22 | — | — | EP | disclosed |