Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 11/20 | 0.39 |
| ▸ | FEN1 | P39748 | 10/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25060659 | 0.84 | ALOX5AP (0.50) | MAPK1ALOX5APFEN1PRF1 | |
| SCHEMBL25060795 | 0.84 | ALOX5AP (0.50) | MAPK1ALOX5APFEN1PRF1 | |
| SCHEMBL25060790 | 0.81 | MAPK1 (0.46) | MAPK1ALOX5APFEN1PARP10PARP11 | |
| SCHEMBL20091533 | 0.76 | MAPK1 (0.59) | MAPK1ALOX5APFEN1PARP10PARP11 | |
| SCHEMBL18123071 | 0.76 | MAPK1 (0.51) | MAPK1ALOX5APFEN1PRF1 | |
| SCHEMBL29914392 | 0.75 | MAPK1 (0.61) | MAPK1ALOX5APFEN1PARP10PARP11 | |
| SCHEMBL24681135 | 0.75 | MAPK1 (0.61) | MAPK1ALOX5APFEN1PARP10PARP11 | |
| SCHEMBL25060612 | 0.75 | MAPK1 (0.55) | MAPK1ALOX5APFEN1PARP10PARP11 | |
| SCHEMBL18113016 | 0.74 | MAPK1 (0.57) | MAPK1ALOX5APFEN1PARP10PARP11 | |
| SCHEMBL18113022 | 0.74 | MAPK1 (0.55) | MAPK1ALOX5APFEN1PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724180-B1 | COMPOUNDS FOR THE DEGRADATION OF STK4 AND TREATMENT OF HEMATOLOGIC MALIGNANCIES | DANA FARBER CANCER INST INC (US) | 2023-02-22 | — | — | EP | disclosed |