Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 3/20 | 0.54 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | F2R | P25116 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074008 | 1.00 | GNAI3 (0.54) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL25074011 | 1.00 | GNAI3 (0.54) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL4420752 | 0.84 | GNAI3 (0.59) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL26042822 | 0.83 | KMT2A (0.51) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL23603458 | 0.82 | GNAI3 (0.45) | GNAI3GNAO1GNAI1ALDH1A1HTT | |
| SCHEMBL25955527 | 0.82 | KMT2A (0.57) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL13812318 | 0.80 | GNAI3 (0.55) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL15171759 | 0.78 | GNAI3 (0.41) | GNAI3GNAO1GNAI1ITGB3ITGA2B | |
| SCHEMBL12049756 | 0.78 | NAMPT (0.50) | GNAI3GNAO1GNAI1HTTTPSAB1 | |
| SCHEMBL27314179 | 0.78 | GNAI3 (0.42) | GNAI3GNAO1GNAI1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |