Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26295618 | 0.83 | HRH3 (0.43) | HRH3ALDH1A1SMN1; SMN2KCNH2HPGD | |
| SCHEMBL25513779 | 0.79 | HRH3 (0.42) | HRH3HSD11B1MEN1KMT2ADPP8 | |
| SCHEMBL18374885 | 0.75 | CHRNB2 (0.53) | HRH3ALDH1A1HSD11B1MAPTHPGD | |
| SCHEMBL26295606 | 0.74 | HRH3 (0.46) | HRH3ALDH1A1HSD11B1KCNH2CYP2D6 | |
| SCHEMBL24870374 | 0.74 | PIK3CD (0.43) | HRH3MEN1KMT2ASMN1; SMN2EPHX2 | |
| SCHEMBL26498812 | 0.73 | HRH3 (0.45) | HRH3DPP8DPP7SIGMAR1KCNH2 | |
| SCHEMBL26295610 | 0.73 | HRH3 (0.40) | HRH3HSD11B1 | |
| SCHEMBL25489003 | 0.72 | HRH3 (0.54) | HRH3ALDH1A1HSD11B1DPP8DPP7 | |
| SCHEMBL26295566 | 0.72 | CHRNB2 (0.42) | HRH3ALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL26498816 | 0.72 | HRH3 (0.35) | HRH3ALDH1A1HSD11B1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |