Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26820204 | 1.00 | IAPP (0.54) | IAPPPTGS1TDP1GLANFE2L2 | |
| SCHEMBL2134058 | 0.84 | KDM4E (0.53) | TDP1GLANFE2L2APPGAA | |
| SCHEMBL2134056 | 0.84 | KDM4E (0.53) | TDP1GLANFE2L2APPGAA | |
| SCHEMBL29136998 | 0.82 | TTR (0.58) | NFE2L2FDPSAPPGAAHTT | |
| SCHEMBL29879436 | 0.82 | TTR (0.58) | NFE2L2FDPSAPPGAAHTT | |
| SCHEMBL13719066 | 0.82 | IP6K1 (0.42) | IAPPPTGS1NFE2L2APPSMARCA2 | |
| SCHEMBL24738883 | 0.82 | TTR (0.58) | NFE2L2FDPSAPPGAAHTT | |
| SCHEMBL4089000 | 0.82 | IP6K1 (0.42) | IAPPPTGS1NFE2L2APPSMARCA2 | |
| SCHEMBL17053206 | 0.81 | IAPP (0.51) | IAPPPTGS1TDP1GLAFDPS | |
| SCHEMBL4573175 | 0.81 | IAPP (0.51) | IAPPPTGS1TDP1GLAFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023020479-A1 | PARP7 INHIBITOR AND APPLICATION THEREOF | 重庆华森制药股份有限公司 | 2023-02-23 | — | — | WO | disclosed |