Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.52 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.43 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27380463 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL24309126 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL16132848 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL21287989 | 0.87 | CHRNB2 (0.40) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL24870374 | 0.84 | PIK3CD (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4PIK3CD | |
| SCHEMBL24870383 | 0.84 | CHRNB2 (0.38) | CHRNB2CHRNA3CHRNA4CHRNB4PIK3CD | |
| SCHEMBL26295565 | 0.81 | CHRNB2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL14453854 | 0.81 | CHRNB2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 | |
| SCHEMBL23325422 | 0.79 | HSD17B10 (0.41) | HRH4TLR9TLR8TLR7SMN1; SMN2 | |
| SCHEMBL15218142 | 0.79 | CHRNB2 (0.40) | CHRNB2CHRNA3CHRNA4CHRNB4CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |