Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14336925 | 0.83 | MAPT (0.33) | MAPTCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL16002903 | 0.83 | MEN1 (0.41) | MAPTALDH1A1 | |
| SCHEMBL16837171 | 0.78 | — | — | |
| SCHEMBL761653 | 0.76 | — | — | |
| SCHEMBL13165512 | 0.75 | MAPT (0.38) | MAPTHTTALDH1A1 | |
| SCHEMBL2617044 | 0.75 | MAPT (0.38) | MAPTHTTALDH1A1 | |
| SCHEMBL13165462 | 0.75 | MAPT (0.38) | MAPTHTTALDH1A1 | |
| SCHEMBL76462 | 0.75 | — | — | |
| SCHEMBL26522637 | 0.75 | HSD11B1 (0.39) | HRH3CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL14877965 | 0.75 | EPHX1 (0.34) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |