Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.56 |
| ▸ | BCHE | P06276 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25079218 | 0.92 | DDB1 (0.59) | DDB1CRBNBCHEKDM4E | |
| SCHEMBL25079676 | 0.81 | ESR1 (0.52) | — | |
| SCHEMBL25079581 | 0.79 | CRBN (0.57) | DDB1CRBNBCHENPC1RAB9A | |
| SCHEMBL25079301 | 0.77 | DDB1 (0.52) | DDB1CRBNBCHENPC1RAB9A | |
| SCHEMBL25079671 | 0.76 | DDB1 (0.69) | DDB1CRBNNPC1RAB9AKMT2A | |
| SCHEMBL25079659 | 0.75 | CRBN (0.58) | DDB1CRBNBCHESMN1; SMN2KDM4E | |
| SCHEMBL24548313 | 0.74 | CRBN (0.47) | DDB1CRBNSMN1; SMN2HTTKMT2A | |
| SCHEMBL24548311 | 0.74 | CRBN (0.57) | DDB1CRBNLMNA | |
| SCHEMBL24847626 | 0.73 | CRBN (0.52) | DDB1CRBNKMT2ALMNAALDH1A1 | |
| SCHEMBL24155474 | 0.72 | CRBN (0.73) | DDB1CRBNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |