Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 10/20 | 0.61 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23142739 | 0.82 | DDB1 (0.62) | DDB1CRBNHSD17B10 | |
| SCHEMBL30257675 | 0.79 | DDB1 (0.64) | DDB1CRBNHSD17B10MEN1KMT2A | |
| SCHEMBL25079169 | 0.79 | CRBN (0.56) | DDB1CRBNHDAC1BRD4CREBBP | |
| SCHEMBL25079638 | 0.79 | DDB1 (0.72) | DDB1CRBNHSD17B10MEN1KMT2A | |
| SCHEMBL38654966 | 0.77 | DDB1 (0.54) | DDB1CRBNBRD4CREBBPL3MBTL1 | |
| SCHEMBL31393572 | 0.76 | DDB1 (0.56) | DDB1CRBNHDAC1BRD4CREBBP | |
| SCHEMBL31040961 | 0.76 | DDB1 (1.00) | DDB1CRBNBRD4CREBBPL3MBTL1 | |
| SCHEMBL25079168 | 0.76 | MAOB (0.55) | HDAC1L3MBTL1 | |
| SCHEMBL17136480 | 0.75 | HDAC1 (0.65) | HDAC1L3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL25079218 | 0.75 | DDB1 (0.59) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |