Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12424318 | 0.83 | ACHE (0.47) | CXCR4PRMT5WDR77ALDH1A1HSD17B10 | |
| SCHEMBL20609083 | 0.82 | CXCR4 (0.68) | CXCR4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL12384576 | 0.80 | CXCR4 (0.40) | CXCR4PRMT5WDR77ACHECTSK | |
| SCHEMBL18157904 | 0.80 | CXCR4 (0.66) | CXCR4ALDH1A1HSD17B10KDM4EHPGD | |
| Bromide SCHEMBL29605492 | 0.78 | CXCR4 (0.63) | CXCR4ALDH1A1HSD17B10KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL29604003 | 0.78 | CXCR4 (0.63) | CXCR4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL1857487 | 0.76 | HRH3 (0.54) | HRH3 | |
| SCHEMBL19013075 | 0.74 | GRM5 (0.45) | ALDH1A1KDM4E | |
| SCHEMBL20919335 | 0.74 | PIM1 (0.36) | CXCR4PRMT5WDR77ALDH1A1KDM4E | |
| SCHEMBL25087419 | 0.74 | JAK2 (0.48) | PRMT5WDR77ALDH1A1KDM4ECTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023027948-A1 | JAK2 INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |