Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | FYN | P06241 | 4/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520772 | 0.86 | JAK2 (0.44) | JAK2FYNPTK2JAK1TNF | |
| SCHEMBL521246 | 0.77 | JAK2 (0.52) | JAK2FYNPTK2JAK1MKNK1 | |
| SCHEMBL2484576 | 0.77 | JAK2 (0.53) | JAK2PTK2 | |
| SCHEMBL519344 | 0.73 | JAK2 (0.48) | JAK2FYNPTK2JAK1MKNK1 | |
| SCHEMBL520956 | 0.73 | JAK2 (0.46) | JAK2FYNPTK2JAK1TNF | |
| SCHEMBL2502680 | 0.69 | ALK (0.54) | JAK2PTK2KCNH2 | |
| SCHEMBL520267 | 0.68 | JAK2 (0.42) | JAK2PTK2KCNH2PTGS1PTGS2 | |
| SCHEMBL2502679 | 0.68 | ALK (0.41) | JAK2PTK2KCNH2 | |
| SCHEMBL520412 | 0.68 | CDK1 (0.41) | JAK2PTK2KCNH2PTGS1PTGS2 | |
| SCHEMBL521240 | 0.67 | JAK2 (0.61) | JAK2PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |