Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 8/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519344 | 0.87 | JAK2 (0.48) | JAK2PTK2FYNHASPINJAK1 | |
| SCHEMBL519880 | 0.78 | JAK2 (0.42) | JAK2PTK2FYNTNF | |
| SCHEMBL521246 | 0.76 | JAK2 (0.52) | JAK2PTK2FYNJAK1KDR | |
| SCHEMBL2509986 | 0.73 | JAK2 (0.47) | JAK2PTK2FYNJAK1KDR | |
| SCHEMBL520772 | 0.70 | JAK2 (0.44) | JAK2PTK2FYNJAK1KDR | |
| SCHEMBL521240 | 0.66 | JAK2 (0.61) | JAK2PTK2JAK1INSRALK | |
| SCHEMBL531103 | 0.66 | JAK2 (0.73) | JAK2PTK2INSRALK | |
| SCHEMBL520662 | 0.65 | INSR (0.44) | JAK2PTK2FYNKDRINSR | |
| SCHEMBL520114 | 0.65 | JAK2 (0.66) | JAK2PTK2FYNINSRALK | |
| SCHEMBL521874 | 0.65 | JAK2 (0.67) | JAK2PTK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | JAK2 1/4885PTK2 592/4885FYN 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.