Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234150 | 0.82 | HTR7 (0.49) | POLBDRD2DRD3DRD4 | |
| SCHEMBL30905277 | 0.76 | POLB (0.82) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL29728649 | 0.76 | MEN1 (0.58) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL31230156 | 0.75 | POLB (0.58) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL6267953 | 0.75 | POLB (0.58) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL432918 | 0.74 | MEN1 (0.54) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL10844596 | 0.74 | CHRM2 (0.71) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL15925412 | 0.74 | POLB (0.60) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL5612798 | 0.74 | POLB (0.57) | MEN1KMT2APOLBCYP1A2CYP2C9 | |
| SCHEMBL12900597 | 0.74 | SCN9A (0.48) | POLBDRD2DRD3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2378879-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Corp. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010071741-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME CORP. (US) | 2010-06-24 | — | — | WO | disclosed |