Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.58 |
| ▸ | NPM1 | P06748 | 13/20 | 0.58 |
| ▸ | INSR | P06213 | 12/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521002 | 0.89 | ALK (0.71) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL519844 | 0.85 | ALK (0.77) | ALKNPM1INSRJAK2 | |
| SCHEMBL2509799 | 0.85 | ALK (0.58) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL2510622 | 0.84 | ALK (0.60) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL520098 | 0.83 | ALK (0.71) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL520468 | 0.79 | ALK (0.77) | ALKNPM1INSRJAK2 | |
| SCHEMBL2522168 | 0.79 | ALK (0.59) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL2522445 | 0.79 | ALK (0.61) | ALKNPM1INSRJAK2 | |
| SCHEMBL520483 | 0.79 | JAK2 (0.82) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL2522544 | 0.79 | ALK (0.73) | ALKNPM1INSRJAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |