Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 9/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 9/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473999 | 1.00 | TLK2 (0.69) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL20763 | 0.85 | TLK2 (0.70) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL20762 | 0.85 | TLK2 (0.70) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL5369374 | 0.81 | TLK2 (0.71) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL20229 | 0.80 | RET (0.64) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL20228 | 0.80 | RET (0.64) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL5728025 | 0.79 | TLK2 (1.00) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL5728024 | 0.79 | TLK2 (1.00) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL5374151 | 0.76 | PDPK1 (0.78) | TLK2PDPK1NTRK1RETPDGFRB | |
| SCHEMBL12474012 | 0.75 | TLK2 (0.38) | TLK2PDPK1RETPDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | claimed |
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | disclosed |