Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25111 | 0.75 | TLK2 (0.69) | TLK2RETKDRPDPK1PDGFRA | |
| SCHEMBL12473999 | 0.75 | TLK2 (0.69) | TLK2RETKDRPDPK1PDGFRA | |
| SCHEMBL20229 | 0.74 | RET (0.64) | TLK2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20228 | 0.74 | RET (0.64) | TLK2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21604 | 0.65 | GAA (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL31718452 | 0.64 | MAOA (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27869713 | 0.63 | ALDH1A1 (0.49) | TLK2RET | |
| SCHEMBL20763 | 0.59 | TLK2 (0.70) | TLK2RETKDRPDPK1PDGFRA | |
| SCHEMBL20762 | 0.59 | TLK2 (0.70) | TLK2RETKDRPDPK1PDGFRA | |
| SCHEMBL26564909 | 0.59 | HDAC1 (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | claimed |