Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 8/20 | 0.79 |
| ▸ | HTT | P42858 | 4/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.79 |
| ▸ | PLK1 | P53350 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | MITF | O75030 | 1/20 | 0.72 |
| ▸ | XBP1 | P17861 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.69 |
| ▸ | RELA | Q04206 | 2/20 | 0.69 |
| ▸ | DPP4 | P27487 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25119646 | 0.88 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL25119620 | 0.88 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL25119658 | 0.88 | NPC1 (0.79) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL25119870 | 0.88 | NPC1 (0.79) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL3501048 | 0.87 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL3501054 | 0.87 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL25119671 | 0.84 | NPC1 (0.73) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL25119640 | 0.82 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL29209514 | 0.82 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL25119614 | 0.80 | NPC1 (0.70) | NPC1SMN1; SMN2RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230097420-A1 | INDAZOLE HYDRAZIDE COMPOUND AND APPLICATION THEREOF | PEKING UNIVERSITY FIRST HOSPITAL (CN) | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230097420-A1 | INDAZOLE HYDRAZIDE COMPOUND AND APPLICATION THEREOF | ITGB3, AR, HDAC3 | NPC1 3708/4885SMN1; SMN2 4858/4885RAB9A 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.