Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.41 |
| ▸ | TXK | P42681 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633934 | 0.87 | BTK (0.49) | BTKABCB11KDRBRD4EPHB4 | |
| SCHEMBL14650714 | 0.86 | BTK (0.48) | BTKABCB11KDRBRD4EPHB4 | |
| SCHEMBL2465824 | 0.85 | EPHB4 (0.49) | BTKABCB11KDREPHB4LYN | |
| SCHEMBL14633944 | 0.85 | BTK (0.45) | BTKABCB11KDRBRD4EPHB4 | |
| SCHEMBL14633535 | 0.84 | GRM4 (0.46) | BTKABCB11KDRBRD4EPHB4 | |
| SCHEMBL14634174 | 0.83 | RIPK2 (0.49) | BTKABCB11KDREPHB4LYN | |
| SCHEMBL14634250 | 0.83 | TRPA1 (0.48) | BTKABCB11KDRBRD4EPHB4 | |
| SCHEMBL14633919 | 0.80 | BTK (0.43) | BTKABCB11KDREPHB4LYN | |
| Trifluoroacetic Acid SCHEMBL14634066 | 0.80 | BTK (0.41) | BTKABCB11KDREPHB4LYN | |
| SCHEMBL14650740 | 0.80 | BTK (0.48) | BTKABCB11KDRBRD4EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552211-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | BTK 215/4885ABCB11 3476/4885KDR 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.