Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 8/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25124219 | 0.92 | PTPN11 (0.48) | PTPN11CYP11B1CYP11B2EGFRKCNH2 | |
| SCHEMBL25713879 | 0.77 | PTPN11 (0.71) | PTPN11EGFRKCNH2 | |
| SCHEMBL25124241 | 0.75 | PTPN11 (0.53) | PTPN11 | |
| SCHEMBL29479101 | 0.72 | PTPN11 (0.73) | PTPN11EGFRKCNH2 | |
| SCHEMBL20415589 | 0.72 | PTPN11 (0.73) | PTPN11EGFRKCNH2 | |
| SCHEMBL25124214 | 0.71 | PTPN11 (0.51) | PTPN11CYP11B1CYP11B2EGFRKCNH2 | |
| SCHEMBL23510860 | 0.70 | PTPN11 (0.40) | PTPN11CYP11B1CYP11B2EGFRKCNH2 | |
| SCHEMBL20909363 | 0.70 | PTPN11 (0.69) | PTPN11EGFRKCNH2CNR2 | |
| SCHEMBL19785104 | 0.69 | PTPN11 (0.70) | PTPN11 | |
| SCHEMBL20417888 | 0.69 | PTPN11 (0.60) | PTPN11CYP11B1CYP11B2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571189-B1 | PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-03-29 | — | — | EP | disclosed |