Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782658 | 0.86 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSIGF1R | |
| SCHEMBL8550947 | 0.86 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSIGF1R | |
| SCHEMBL1665015 | 0.86 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457597 | 0.86 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSIGF1R | |
| SCHEMBL8623095 | 0.85 | KDM4E (0.50) | KDM4EMAPTTHRBHPGDSIGF1R | |
| SCHEMBL1662413 | 0.84 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457485 | 0.84 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457438 | 0.84 | KDM4E (0.50) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457400 | 0.84 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457698 | 0.84 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9867826-B2 | Heterocycles as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2018-01-16 | — | — | US | disclosed |
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| EP-2379524-A1 | SEROTONIN 5-HT2B RECEPTOR INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010080357-A1 | SEROTONIN 5-HT2B RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |