Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2512441 | 0.86 | KDM4E (0.52) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL14782658 | 0.85 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL1665015 | 0.85 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457597 | 0.85 | KDM4E (0.51) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL8623095 | 0.84 | KDM4E (0.50) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL1662413 | 0.83 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457400 | 0.83 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457438 | 0.83 | KDM4E (0.50) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457485 | 0.83 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 | |
| SCHEMBL16457698 | 0.83 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |