⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239458 | 0.95 | — | — | |
| SCHEMBL9581761 | 0.95 | — | — | |
| Water SCHEMBL3133097 | 0.90 | — | — | |
| SCHEMBL11129130 | 0.90 | — | — | |
| SCHEMBL27596874 | 0.89 | — | — | |
| SCHEMBL48883 | 0.89 | — | — | |
| Ammonia Solution, Strong SCHEMBL6551274 | 0.84 | — | — | |
| SCHEMBL476442 | 0.84 | — | — | |
| SCHEMBL8149703 | 0.84 | — | — | |
| Water SCHEMBL22582743 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2562158-A1 | Processes for the preparation of n-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes | Vertex Pharmaceuticals Incorporated (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-1603878-B1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | VERTEX PHARMA (US) | 2013-01-02 | — | — | EP | disclosed |
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | US | disclosed |
| US-8034950-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| CN-101723891-A | Processes for the preparation of N-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes | VERTEX PHARMA | 2010-06-09 | — | — | CN | disclosed |
| CN-100579965-C | Process for preparing N-heteroaryl-N-arylamines by reacting N-aryl carbamates with haloheteroaryls and analogous processes | VERTEX PHARMA CO LTD | 2010-01-13 | — | — | CN | disclosed |
| CN-101312939-A | Heterocyclic cetp inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2008-11-26 | — | — | CN | disclosed |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-26 | — | — | US | disclosed |
| US-7115746-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-10-03 | — | — | US | disclosed |
| CN-1761653-A | Process for preparing N-heteroaryl-N-arylamines by reacting N-aryl carbamates with haloheteroaryls and analogous processes | VERTEX PHARMA (US) | 2006-04-19 | — | — | CN | disclosed |
| EP-1603878-A1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | Vertex Pharmaceuticals Incorporated (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040230058-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-11-18 | — | — | US | disclosed |
| WO-2004072038-A1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-08-26 | — | — | WO | disclosed |