Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450141 | 0.78 | TDP1 (0.44) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL6688207 | 0.75 | SCN5A (0.50) | CYP1A2ALDH1A1ERCC5FEN1 | |
| SCHEMBL11106587 | 0.74 | TDP1 (0.44) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL19469555 | 0.73 | TSHR (0.50) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL22898323 | 0.73 | TDP1 (0.50) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL10401763 | 0.72 | TSHR (0.54) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL10946548 | 0.72 | MAPT (0.39) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL8591916 | 0.71 | TSHR (0.48) | TDP1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL20425406 | 0.71 | TSHR (0.44) | TDP1TSHRCYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL10880336 | 0.71 | TDP1 (0.44) | TDP1TSHRCYP3A4MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379553-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010083141-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-22 | — | — | WO | disclosed |