Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 8/20 | 0.44 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 4/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29928133 | 1.00 | CRBN (0.44) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL29928166 | 0.97 | CRBN (0.43) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL29132187 | 0.97 | CRBN (0.43) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL25133969 | 0.97 | CRBN (0.43) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL31129378 | 0.93 | IKZF2 (0.49) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL27270975 | 0.92 | IKZF2 (0.50) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL29927258 | 0.92 | CRBN (0.51) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL20231931 | 0.92 | CRBN (0.51) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL27271517 | 0.90 | IKZF2 (0.48) | CRBNIKZF3IKZF2IKZF1DDB1 | |
| SCHEMBL31129642 | 0.88 | IKZF2 (0.48) | CRBNIKZF3IKZF2IKZF1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230097358-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230097358-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | LRRK2, CRBN, MDM2 | CRBN 2/4885IKZF3 1511/4885IKZF2 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.