Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | PKM | P14618 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexindoprofen SCHEMBL286896 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| (R)-Indoprofen SCHEMBL30910963 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| Indoprofen SCHEMBL10600175 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| Indoprofen SCHEMBL29361927 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| (R)-Indoprofen SCHEMBL30910962 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| (R)-Indoprofen SCHEMBL5419435 | 1.00 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| Indoprofen SCHEMBL10850545 | 0.99 | NPC1 (0.97) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL10115277 | 0.92 | NPC1 (0.85) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL15695571 | 0.92 | NPC1 (0.85) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL11550044 | 0.90 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 24095 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260000741-A1 | METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE | ACERAGEN INC (US) | 2026-01-01 | — | — | US | claimed |
| EP-3699174-B1 | COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME | ILAB (KR) | 2025-11-12 | — | — | EP | claimed |
| EP-4637708-A2 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | Novaliq GmbH (DE) | 2025-10-29 | — | — | EP | claimed |
| EP-4628080-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Jeil Pharmaceutical Co., Ltd. (KR) | 2025-10-08 | — | — | EP | claimed |
| US-20250256009-A1 | DECELLULARIZED BIOMATERIAL FROM NON-MAMMALIAN TISSUE | NEXTGEN BIOLOGICS, INC. (US) | 2025-08-14 | — | — | US | claimed |
| EP-3795141-B1 | SOLID SOLUTION COMPOSITIONS | INFIRST HEALTHCARE LTD (GB) | 2025-07-30 | — | — | EP | claimed |
| CN-120117987-A | Arylalkanoic acid phloroglucinol ester compound, preparation method and application thereof | 南华大学 | 2025-06-10 | — | — | CN | claimed |
| CN-120040394-A | Method for preparing chiral furanone ester derivative | 北京化工大学 | 2025-05-27 | — | — | CN | claimed |
| WO-2024133913-A9 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING HYOSCYAMINE | NOVALIQ GMBH (DE) | 2025-03-20 | — | — | WO | claimed |
| CN-119424309-A | Compound phospholipid gel sustained release preparation for postoperative analgesia | 四川大学 | 2025-02-14 | — | — | CN | claimed |
| US-4367176-A | Esters of arylpropionic acids endowed with an anti-inflammatory activity and related pharmaceutical compositions | AUSONIA FARMACEUTICI S.R.L. (IT) | 1983-01-04 | — | — | US | claimed |
| US-4347373-A | Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole | TURCONI FRANCO | 1982-08-31 | — | — | US | claimed |
| EP-0055870-A1 | Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same | MERCK & CO. INC. (US) | 1982-07-14 | — | — | EP | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| US-4316884-A | MICROENCAPSULATION, COMPRESSION | ADRIA LABORATORIES, INC. (US) | 1982-02-23 | — | — | US | claimed |
| EP-0039051-A2 | Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | claimed |
| EP-0036684-A1 | Derivatives of 4-methyl-5-(2-aminoethyl)-thiomethyl-imidazole having therapeutic activity | Turconi, Franco (IT) | 1981-09-30 | — | — | EP | claimed |
| US-4242353-A | 4-(1,3-DIHYDRO-1-OXO-2H-ISOINDOL-2-YL)-A-METHYLBENZENEACETIC ACID AND ACETAMINOPHEN | MCNEILAB, INC. (US) | 1980-12-30 | — | — | US | claimed |
| EP-0012621-A1 | Analgesic composition comprising acetaminophen as a potentiating agent | McNeilab, Inc. (US) | 1980-06-25 | — | — | EP | claimed |
| US-4010274-A | ANTICOAGULANT | CARLO ERBA (IT) | 1977-03-01 | — | — | US | claimed |