Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.97 |
| ▸ | RAB9A | P51151 | 4/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.97 |
| ▸ | PKM | P14618 | 3/20 | 0.97 |
| ▸ | TP53 | P04637 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | PGR | P06401 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | GAA | P10253 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | DRD1 | P21728 | 1/20 | 0.97 |
| ▸ | HTT | P42858 | 1/20 | 0.97 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.97 |
| ▸ | RELA | Q04206 | 1/20 | 0.97 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indoprofen SCHEMBL10600175 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| Indoprofen SCHEMBL29361927 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| (R)-Indoprofen SCHEMBL30910963 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| (R)-Indoprofen SCHEMBL5419435 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| (R)-Indoprofen SCHEMBL30910962 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| Dexindoprofen SCHEMBL286896 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| Indoprofen SCHEMBL25137 | 0.99 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL10115277 | 0.91 | NPC1 (0.85) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL15695571 | 0.91 | NPC1 (0.85) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL11550044 | 0.88 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260053978-A1 | Biodegradable Metallic - Polymeric Composite Prosthesis for Heart Valve Replacement | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2026-02-26 | — | — | US | disclosed |
| US-20260049177-A1 | PREPOLYMERS AND COMBINATIONS THEREWITH FOR WOUND REGENERATION | Sunnybrook Research Institute (US) | 2026-02-19 | — | — | US | disclosed |
| US-12544213-B2 | Bioerodible wraps and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2026-02-10 | — | — | US | disclosed |
| EP-3347063-B1 | BI-LAYER EXTRA CELLULAR MATRIX SCAFFOLDS AND USES THEREFOR | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2025-11-19 | — | — | EP | disclosed |
| EP-4615512-A1 | PREPOLYMERS AND COMBINATIONS THEREWITH FOR WOUND REGENERATION | Sunnybrook Research Institute (CA) | 2025-09-17 | — | — | EP | disclosed |
| US-20250242027-A1 | Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells | VANDERBILT UNIVERSITY | 2025-07-31 | — | — | US | disclosed |
| US-20250144035-A1 | Method of Increasing Epithelial Permeability Using Nanoparticles | CARNEGIE MELLON UNIVERSITY | 2025-05-08 | — | — | US | disclosed |
| US-12280112-B2 | Magnetic delivery system and hydrogel fixative for therapeutic cells | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2025-04-22 | — | — | US | disclosed |
| WO-2025034963-A9 | CHOLESTEROL-OLIGONUCLEOTIDE TETHERS WITH APTAMERS FOR LIGAND DISPLAY AND EXTRACELLULAR VESICLE FUNCTIONALIZATION | CARNEGIE MELLON UNIVERSITY (US) | 2025-04-10 | — | — | WO | disclosed |
| US-12268773-B2 | Shear-thinning therapeutic composition, and related methods | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2025-04-08 | — | — | US | disclosed |
| US-20210113519-A1 | Compositions and Methods for Modulating Permeability of Biological Barriers | CARNEGIE MELLON UNIVERSITY | 2021-04-22 | — | — | US | disclosed |
| EP-3755267-A1 | EXTRACTS FOR THE REGENERATION OF LIGAMENTS | University of Pittsburgh - of the Commonwealth System of Higher Education (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3651789-A1 | METHOD OF INCREASING EPITHELIAL PERMEABILITY USING NANOPARTICLES | Carnegie Mellon University (US) | 2020-05-20 | — | — | EP | disclosed |
| US-20200129444-A1 | Method of Increasing Epithelial Permeability Using Nanoparticles | CARNEGIE MELLON UNIVERSITY | 2020-04-30 | — | — | US | disclosed |
| WO-2019204434-A1 | COMPOSITIONS AND METHODS FOR MODULATING PERMEABILITY OF BIOLOGICAL BARRIERS | CARNEGIE MELLON UNIVERSITY (US) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019165185-A1 | EXTRACTS FOR THE REGENERATION OF LIGAMENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-08-29 | — | — | WO | disclosed |
| CN-105142611-B | Topical composition and the method for treating topical condition | 佩丽泰克医药有限公司 | 2019-06-04 | — | — | CN | disclosed |
| WO-2019014559-A1 | METHOD OF INCREASING EPITHELIAL PERMEABILITY USING NANOPARTICLES | CARNEGIE MELLON UNIVERSITY (US) | 2019-01-17 | — | — | WO | disclosed |
| CN-105142611-A | Topical compositions and methods of treatment of topical disorders | PERITECH PHARMA LTD | 2015-12-09 | — | — | CN | disclosed |
| EP-0167958-A2 | Oral solid pharmaceutical form with sequential action for the administering of drugs with ulcerogenic side effect | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) | 1986-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12544213-B2 | Bioerodible wraps and uses therefor | MEF2D, TNNT2, VEGFA | PTGS2 3087/4885NPC1 4355/4885RAB9A 3866/4885 |
| US-20210113519-A1 | Compositions and Methods for Modulating Permeability of Biological Barriers | FABP2, SI, VIP | PTGS2 643/4885NPC1 805/4885RAB9A 1813/4885 |
| US-20260049177-A1 | PREPOLYMERS AND COMBINATIONS THEREWITH FOR WOUND REGENERATION | PREP, ANPEP, SPPL2B | PTGS2 566/4885NPC1 4550/4885RAB9A 3519/4885 |
| US-20260053978-A1 | Biodegradable Metallic - Polymeric Composite Prosthesis for Heart Valve Replacement | TNNT2, EED, CAD | PTGS2 1848/4885NPC1 4554/4885RAB9A 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.