Pyrene

Pyrene

SCHEMBL251380

COP(=O)(O)O.c1cc2ccc3cccc4ccc(c1)c2c34

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
HPGD P15428 4/20 0.50
HSD17B10 Q99714 3/20 0.50
CYP3A4 P08684 3/20 0.50
TSHR P16473 3/20 0.50
CYP1A2 P05177 2/20 0.50
CYP1A1 P04798 2/20 0.50
CYP1B1 Q16678 2/20 0.50
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
INPPL1 O15357 1/20 0.39
INPP5B P32019 1/20 0.39
INPP5A Q14642 1/20 0.39
TYMS P04818 1/20 0.38
PTK2B Q14289 1/20 0.37
SRC P12931 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrene SCHEMBL21437358 0.84 ALDH1A1 (0.52) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Naphthalene SCHEMBL9123208 0.83 SRC (0.46) CYP1A2MEN1KMT2AINPPL1INPP5B
Pyrene SCHEMBL28121783 0.83 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Pyrene SCHEMBL28404441 0.83 ALDH1A1 (0.65) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Pyrene SCHEMBL38652674 0.79 HPGD (0.44) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Anthracene SCHEMBL29044783 0.79 SRC (0.48) ALDH1A1HPGDCYP1A2MEN1KMT2A
Pyrene SCHEMBL27692905 0.78 ALDH1A1 (0.58) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Pyrene SCHEMBL27947559 0.78 ALDH1A1 (0.58) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Pyrene SCHEMBL1829255 0.74 ALDH1A1 (0.79) ALDH1A1HPGDHSD17B10CYP3A4TSHR
Pyrene SCHEMBL28304707 0.74 ALDH1A1 (0.79) ALDH1A1HPGDHSD17B10CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088561-B2 Method of making a lithographic printing plate AGFA GRAPHICS NV (BE) 2012-01-03 US disclosed
CN-101341026-B Method for making lithographic printing plate AGFA GRAPHICS NV 2010-05-19 CN disclosed
EP-1957273-B1 METHOD OF MAKING A LITHOGRAPHIC PRINTING PLATE AGFA GRAPHICS NV (BE) 2009-08-19 EP disclosed
CN-101341026-A Method for making lithographic printing plate AGFA GRAPHICS NV (BE) 2009-01-07 CN disclosed
US-20080307990-A1 Method of Making a Lithographic Printing Plate AGFA GRAPHICS NV (BE) 2008-12-18 US disclosed
EP-1957273-A1 METHOD OF MAKING A LITHOGRAPHIC PRINTING PLATE AGFA GRAPHICS NV (BE) 2008-08-20 EP disclosed
WO-2007060200-A1 METHOD OF MAKING A LITHOGRAPHIC PRINTING PLATE AGFA GRAPHICS NV (BE) 2007-05-31 WO disclosed
EP-1057623-B1 A method for preparing a lithographic printing plate by laser ablation of a heat-sensitive imaging element AGFA GEVAERT (BE) 2004-05-06 EP disclosed
US-6489078-B1 IR radiation-sensitive imaging element and a method for producing lithographic plates therewith AGFA-GEVAERT (BE) 2002-12-03 US disclosed
US-6455230-B1 IMAGEWISE EXPOSING IMAGING HEAT-SENSITIVE COMPOSITION WITH HIGH INTENSITY LASER, AT LEAST PARTIALLY REMOVING HEAT-SENSITIVE COMPOSITION TO EXPOSE LITHOGRAPHIC SUPPORT AGFA-GEVAERT (BE) 2002-09-24 US disclosed
US-6033740-A Method for making positive working printing plates from a lithographic base comprising a flexible support having a hardened hydrophilic substrate AGFA-GEVAERT, N.V. (BE) 2000-03-07 US disclosed
US-5994023-A IMAGING ELEMENT FOR LITHOGRAPHIC PRINTING PLATE AGFA-GEVAERT, N.V. (BE) 1999-11-30 US disclosed
EP-0924064-A1 A method for making positive working printing plates from a lithographic base comprising a flexible support having a hardened hydrophilic substrate AGFA-GEVAERT N.V. (BE) 1999-06-23 EP disclosed
US-5908731-A Heat sensitive imaging element and a method for producing lithographic plates therewith AGFA-GEVAERT, N.V. (BE) 1999-06-01 US disclosed
EP-0819980-A1 An IR radiation-sensitive imaging element and a method for producing lithographic plates therewith AGFA-GEVAERT N.V. (BE) 1998-01-21 EP disclosed
EP-0819985-A1 A radiation sensitive imaging element and a method for producing lithographic plates therewith AGFA-GEVAERT N.V. (BE) 1998-01-21 EP disclosed
EP-0819986-A1 An acid-sensitive substance and photosensitive compositions therewith AGFA-GEVAERT N.V. (BE) 1998-01-21 EP disclosed
EP-0816071-A1 A heat sensitive imaging element and a method for producing lithographic plates therewith AGFA-GEVAERT N.V. (BE) 1998-01-07 EP disclosed
US-5624785-A Imaging element comprising a photoacid-sensitive composition and a method for producing lithographic plates therewith AGFA-GEVAERT, N.V. (BE) 1997-04-29 US disclosed
EP-0738932-A2 Imaging element comprising a photoacid-sensitive composition and a method for producing lithographic plates therewith AGFA-GEVAERT N.V. (BE) 1996-10-23 EP disclosed