SCHEMBL25142467

SCHEMBL25142467

Cc1ccc(I)cc1C(=O)Nc1nc(C)c(C)s1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 13/20 0.58
NPC1 O15118 10/20 0.58
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
RXFP1 Q9HBX9 2/20 0.58
PKM P14618 3/20 0.55
SMN1; SMN2 Q16637 8/20 0.52
MAPT P10636 4/20 0.52
TP53 P04637 3/20 0.52
HTT P42858 2/20 0.52
HSD17B10 Q99714 2/20 0.52
NFKB1 P19838 1/20 0.52
NFKB2 Q00653 1/20 0.52
RELA Q04206 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
MCOLN3 Q8TDD5 1/20 0.52
ALDH1A1 P00352 2/20 0.49
CSNK2A2 P19784 1/20 0.46
CSNK2B P67870 1/20 0.46
CSNK2A1 P68400 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31665061 1.00 RAB9A (0.58) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL25142625 0.86 RAB9A (0.60) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL25143604 0.84 RAB9A (0.58) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL31665569 0.84 RAB9A (0.58) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL25063325 0.82 RAB9A (0.53) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL31665465 0.81 MAPT (0.56) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL25142454 0.80 RAB9A (0.76) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL31665068 0.80 RAB9A (0.76) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL16073066 0.78 RAB9A (0.60) RAB9ANPC1MEN1KMT2ARXFP1
SCHEMBL25143103 0.78 RAB9A (0.51) RAB9ANPC1MEN1KMT2ARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023061440-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-04-20 WO disclosed