Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11506155 | 0.83 | PRMT5 (0.54) | MEN1KMT2AHTTPRMT5TP53 | |
| SCHEMBL10412483 | 0.83 | MEN1 (0.52) | MEN1KMT2AHTTPRMT5TP53 | |
| SCHEMBL18258180 | 0.83 | KAT2B (0.40) | MEN1KMT2AHTTPRMT5TP53 | |
| SCHEMBL3970730 | 0.79 | TP53 (0.55) | MEN1KMT2AHTTPRMT5TP53 | |
| SCHEMBL20532867 | 0.79 | KAT2B (0.40) | MEN1KMT2AHTTTP53KDM4E | |
| SCHEMBL18247618 | 0.79 | KAT2B (0.40) | MEN1KMT2AHTTTP53KDM4E | |
| SCHEMBL18247617 | 0.79 | KAT2B (0.40) | MEN1KMT2AHTTTP53KDM4E | |
| SCHEMBL8877177 | 0.78 | PRMT5 (0.50) | MEN1KMT2AHTTPRMT5TP53 | |
| SCHEMBL20853336 | 0.78 | PRMT5 (0.49) | MEN1KMT2AHTTPRMT5TP53 | |
| SCHEMBL4098781 | 0.77 | KAT2B (0.47) | MEN1KMT2AHTTHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298003-B1 | BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2023-04-19 | — | — | EP | disclosed |