Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 11/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25145034 | 0.89 | PADI4 (0.51) | PADI4CA12CA9PTGER4MAPK1 | |
| SCHEMBL18247513 | 0.89 | PADI4 (0.51) | PADI4CA12CA9PTGER4MAPK1 | |
| SCHEMBL18247694 | 0.88 | PADI4 (0.50) | PADI4CA12CA9PTGER4MAPK1 | |
| Lithium SCHEMBL18247699 | 0.88 | PADI4 (0.50) | PADI4CA12CA9PTGER4MAPK1 | |
| Lithium Ion SCHEMBL30325457 | 0.87 | PADI4 (0.49) | PADI4CA12CA9PTGER4MAPK1 | |
| Lithium Ion SCHEMBL18247696 | 0.87 | PADI4 (0.49) | PADI4CA12CA9PTGER4MAPK1 | |
| SCHEMBL18247704 | 0.86 | PADI4 (0.49) | PADI4CA12CA9PTGER4PDE4A | |
| SCHEMBL25145174 | 0.80 | PTGER4 (0.51) | PADI4CA12CA9PTGER4MAPK1 | |
| SCHEMBL25145092 | 0.80 | PADI4 (0.47) | PADI4CA12CA9PTGER4MAPK1 | |
| SCHEMBL18247673 | 0.78 | PADI4 (0.78) | PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298003-B1 | BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2023-04-19 | — | — | EP | disclosed |