SCHEMBL25147481

SCHEMBL25147481

c1ccc(-c2nc(-c3cccc(-c4ccc(-c5nc(-c6ccccc6)c6oc7cc8c9ccccc9n(-c9nc(-c%10ccccc%10)nc(-c%10cccc(-c%11ccc(-c%12ccc(-c%13nc(-c%14ccccc%14)c%14oc%15cc%16c%17ccccc%17n(-c%17nc(-c%18ccccc%18)c%18ccc%19ccccc%19c%18n%17)c%16cc%15c%14n%13)cc%12)cc%11)c%10)n9)c8cc7c6n5)cc4)c3)nc(-n3c4ccccc4c4cc5oc6c(-c7ccccc7)nc(-c7ccccc7)nc6c5cc43)n2)cc1

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
CYP1A1 P04798 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP1B1 Q16678 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25147260 0.90 TSHR (0.34) TSHRMEN1KMT2AATMCYP1A1
SCHEMBL25147475 0.88 TSHR (0.38) TSHRMEN1KMT2AATMCYP1A2
SCHEMBL25147394 0.86 TSHR (0.39) TSHRMEN1KMT2AATMCYP1A2
SCHEMBL25147060 0.85 TSHR (0.39) TSHRMEN1KMT2AATMCYP1A2
SCHEMBL25147050 0.84 TSHR (0.38) TSHRMEN1KMT2AATMCYP1A2
SCHEMBL25147479 0.83 ALDH1A1 (0.40) TSHRMEN1KMT2AATM
SCHEMBL19636246 0.83
SCHEMBL25147235 0.82 TSHR (0.36) TSHRMEN1KMT2AATMCYP1A2
SCHEMBL25147257 0.82 TSHR (0.38) TSHRMEN1KMT2AATMCYP1A2
SCHEMBL25147526 0.82 TSHR (0.39) TSHRMEN1KMT2AATMCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023061998-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2023-04-20 WO disclosed