Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937175 | 0.80 | PDE10A (0.50) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14845793 | 0.80 | PDE10A (0.50) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21664701 | 0.78 | GPR119 (0.46) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16472352 | 0.78 | GRIN2D (0.49) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL10154595 | 0.78 | GRIN2D (0.49) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22210396 | 0.77 | GRIN2D (0.43) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29496980 | 0.77 | ACACB (0.35) | PRCPHPGDSLRRK2 | |
| SCHEMBL25296122 | 0.77 | ACACB (0.35) | PRCPHPGDSLRRK2 | |
| SCHEMBL16472245 | 0.76 | GRIN2D (0.42) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20133354 | 0.76 | GRIN2D (0.42) | PDE10AGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064585-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |