Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31659520 | 1.00 | KDM4E (0.33) | KDM4EPANK3P2RX3P2RX2 | |
| SCHEMBL25147761 | 0.85 | P2RX3 (0.35) | KDM4EP2RX3P2RX2 | |
| SCHEMBL30331940 | 0.85 | P2RX3 (0.35) | KDM4EP2RX3P2RX2 | |
| SCHEMBL30370412 | 0.85 | KDM4E (0.35) | KDM4EP2RX3P2RX2 | |
| SCHEMBL25153188 | 0.85 | KDM4E (0.35) | KDM4EP2RX3P2RX2 | |
| SCHEMBL25148366 | 0.83 | GRIN2D (0.32) | KDM4EP2RX3P2RX2 | |
| SCHEMBL31659721 | 0.83 | GRIN2D (0.32) | KDM4EP2RX3P2RX2 | |
| SCHEMBL30332146 | 0.81 | GRIN2D (0.31) | — | |
| SCHEMBL25148195 | 0.81 | GRIN2D (0.31) | — | |
| SCHEMBL25147741 | 0.81 | P2RX3 (0.36) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064585-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |