Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197350 | 0.86 | KDM4E (0.69) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25149281 | 0.85 | KDM4E (0.72) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL31547667 | 0.81 | KDM4E (0.61) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25148578 | 0.81 | KDM4E (0.61) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25148579 | 0.80 | KDM4E (0.65) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25149305 | 0.80 | KDM4E (0.65) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL4074628 | 0.79 | KDM4E (1.00) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25148763 | 0.78 | KDM4E (0.58) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL11111623 | 0.78 | KDM4E (0.72) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25148757 | 0.76 | KDM4E (0.51) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |