Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25149490 | 0.86 | KDM4E (0.65) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL4074628 | 0.82 | KDM4E (1.00) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL11116264 | 0.82 | KDM4E (0.69) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL11738892 | 0.81 | KDM4E (0.63) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL11733491 | 0.81 | KDM4E (0.63) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25149281 | 0.81 | KDM4E (0.72) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL11255696 | 0.80 | KDM4E (0.61) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL25148578 | 0.80 | KDM4E (0.61) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL31547667 | 0.80 | KDM4E (0.61) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL21686405 | 0.80 | KDM4E (0.65) | KDM4EAKR1C2AKR1C1PIN1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043924-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |