Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29528441 | 0.89 | NPC1 (0.58) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3954455 | 0.89 | NPC1 (0.58) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2367798 | 0.89 | NPC1 (0.58) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3415364 | 0.89 | NPC1 (0.58) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14498451 | 0.78 | NPC1 (0.44) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL23944688 | 0.76 | NPC1 (0.43) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL22365583 | 0.76 | NPC1 (0.43) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL16325449 | 0.75 | NPC1 (0.56) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL19010013 | 0.73 | NPC1 (0.74) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL21162136 | 0.72 | MAPT (0.47) | NPC1MAPTRAB9ASMN1; SMN2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370207-A1 | HYDROGENATION OF ESTER, KETONE OR ALDEHYDE GROUPS WITH RUTHENIUM COMPLEXES HAVING A DI-AMINE AND A PHOSPHOROUS-NITROGEN BIDENTATE LIGAND | Firmenich S.A. (CH) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010061350-A1 | HYDROGENATION OF ESTER, KETONE OR ALDEHYDE GROUPS WITH RUTHENIUM COMPLEXES HAVING A DI-AMINE AND A PHOSPHOROUS-NITROGEN BIDENTATE LIGAND | FIRMENICH SA (CH) | 2010-06-03 | — | — | WO | disclosed |