Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15913096 | 0.88 | MEN1 (0.43) | MEN1KMT2AGAAALOX12ALOX15 | |
| SCHEMBL1148744 | 0.82 | MEN1 (0.42) | MEN1KMT2AGAAALOX12ALOX15 | |
| SCHEMBL1148575 | 0.77 | MEN1 (0.41) | MEN1KMT2AGAAALOX12ALOX15 | |
| SCHEMBL2517410 | 0.76 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1IDO1NOX1 | |
| SCHEMBL14609912 | 0.75 | KMT2A (0.35) | MEN1KMT2AGAAALOX12MAPT | |
| SCHEMBL1147836 | 0.72 | MEN1 (0.42) | MEN1KMT2AGAAALOX12ALOX15 | |
| SCHEMBL1148583 | 0.72 | MAPT (0.35) | MEN1KMT2AGAAALOX12MAPT | |
| SCHEMBL1147973 | 0.71 | HSP90AA1 (0.36) | MEN1KMT2AGAAALOX12ALOX15 | |
| SCHEMBL14609862 | 0.70 | KMT2A (0.35) | MEN1KMT2AGAAALOX12MAPT | |
| SCHEMBL1147887 | 0.70 | MEN1 (0.44) | MEN1KMT2AGAAALOX12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034834-B2 | Method for treating proliferative disorders with HSP90 inhibitors | SYNTA PHARMACEUTICALS CORP. (US) | 2011-10-11 | — | — | US | disclosed |