Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148531 | 0.82 | CHEK1 (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL15913096 | 0.78 | MEN1 (0.43) | HSP90AA1HSP90AB1NOX1IDO1TEK | |
| SCHEMBL2515290 | 0.76 | MEN1 (0.40) | HSP90AA1HSP90AB1NOX1IDO1 | |
| SCHEMBL2517374 | 0.75 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1HSP90B1TRAP1TRPV1 | |
| SCHEMBL1147883 | 0.75 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148623 | 0.73 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148835 | 0.72 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148566 | 0.72 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1 | |
| SCHEMBL12047190 | 0.72 | HSP90AB1 (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148555 | 0.72 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034834-B2 | Method for treating proliferative disorders with HSP90 inhibitors | SYNTA PHARMACEUTICALS CORP. (US) | 2011-10-11 | — | — | US | disclosed |