Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | NPY4R | P50391 | 3/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353738 | 0.84 | SIRT2 (0.49) | FOLH1HTT | |
| Arginine SCHEMBL4282364 | 0.83 | SLC1A3 (0.55) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| SCHEMBL3362561 | 0.82 | DPP8 (0.50) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| SCHEMBL22133069 | 0.82 | DPP8 (0.50) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| SCHEMBL7758995 | 0.82 | DPP8 (0.50) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| SCHEMBL29448070 | 0.81 | SLC1A1 (0.49) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| Hydrochloric Acid SCHEMBL27766761 | 0.81 | DPP8 (0.49) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| Hydrochloric Acid SCHEMBL27766760 | 0.81 | DPP8 (0.49) | SLC1A1SLC1A3DPP8DPP7FOLH1 | |
| Arginine SCHEMBL17164594 | 0.80 | AKR1B1 (0.45) | SLC1A1SLC1A3ANPEP | |
| Arginine SCHEMBL17164595 | 0.80 | AKR1B1 (0.45) | SLC1A1SLC1A3ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034928-B2 | Fluorescence assays with improved sensitivity | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-10-11 | — | — | US | disclosed |