SCHEMBL25155348

SCHEMBL25155348

NC(c1cccc2ccccc12)C(F)F

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
CYP1A2 P05177 3/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
TSHR P16473 2/20 0.41
HSD17B10 Q99714 2/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
KEAP1 Q14145 1/20 0.41
ACP3 P15309 2/20 0.40
AOC3 Q16853 1/20 0.40
CYP2A6 P11509 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
ADRA2A P08913 3/20 0.38
ADRA2B P18089 3/20 0.38
ADRA2C P18825 3/20 0.38
ADRA1A P35348 3/20 0.38
ADRA1D P25100 2/20 0.38
ADRA1B P35368 2/20 0.38
SLC6A4 P31645 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31360342 1.00 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
Hydrochloric Acid SCHEMBL31360098 0.98 ALDH1A1 (0.50) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
SCHEMBL9906119 0.87 ALDH1A1 (0.60) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
SCHEMBL24017144 0.87 ALDH1A1 (0.60) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
SCHEMBL29887508 0.87 ALDH1A1 (0.60) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
SCHEMBL2067587 0.87 ALDH1A1 (0.60) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
Hydrochloric Acid SCHEMBL14119362 0.85 ALDH1A1 (0.58) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
Hydrochloric Acid SCHEMBL30098262 0.85 ALDH1A1 (0.58) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
Hydrochloric Acid SCHEMBL19951713 0.85 ALDH1A1 (0.58) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR
SCHEMBL12101209 0.79 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2C9CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023064493-A1 COMPOUNDS AND METHODS FOR TREATING CORONAVIRUSES Clear Creek Bio, Inc. (US) 2023-04-20 WO disclosed