Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 8/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25520002 | 0.90 | DYRK1A (0.51) | TDO2CDC7MAP4K4PRKACAGSK3B | |
| SCHEMBL25519993 | 0.88 | TDO2 (0.47) | TDO2GSK3BIRAK4DYRK1ACLK2 | |
| SCHEMBL30346585 | 0.88 | DYRK1A (0.49) | TDO2CDC7CDK1KDRCCNB1 | |
| SCHEMBL25211955 | 0.88 | DYRK1A (0.49) | TDO2CDC7CDK1KDRCCNB1 | |
| SCHEMBL30347581 | 0.88 | TDO2 (0.49) | TDO2MKNK2IRAK4CD38RET | |
| SCHEMBL25519995 | 0.88 | TDO2 (0.49) | TDO2MKNK2IRAK4CD38RET | |
| SCHEMBL30347199 | 0.86 | TDO2 (0.49) | TDO2DYRK1ACLK2CLK3CDK2 | |
| SCHEMBL25157431 | 0.86 | TDO2 (0.49) | TDO2DYRK1ACLK2CLK3CDK2 | |
| SCHEMBL30407075 | 0.86 | TDO2 (0.48) | TDO2IRAK4RETDYRK1ACLK2 | |
| SCHEMBL25520358 | 0.86 | TDO2 (0.48) | TDO2IRAK4RETDYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |