Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 19/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515881 | 1.00 | CCR6 (0.52) | CCR6CXCR2 | |
| SCHEMBL12205526 | 1.00 | CCR6 (0.52) | CCR6CXCR2 | |
| SCHEMBL1580388 | 1.00 | CCR6 (0.52) | CCR6CXCR2 | |
| SCHEMBL2515878 | 1.00 | CCR6 (0.52) | CCR6CXCR2 | |
| SCHEMBL2292688 | 0.91 | CXCR2 (0.63) | CCR6CXCR2 | |
| SCHEMBL2292676 | 0.91 | CXCR2 (0.63) | CCR6CXCR2 | |
| SCHEMBL2292680 | 0.91 | CXCR2 (0.63) | CCR6CXCR2 | |
| SCHEMBL12385834 | 0.91 | CXCR2 (0.63) | CCR6CXCR2 | |
| SCHEMBL2520646 | 0.87 | CCR6 (0.53) | CCR6CXCR2 | |
| SCHEMBL13494940 | 0.87 | CCR6 (0.53) | CCR6CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288588-B2 | Squaramide derivatives as CXCR2 antagonist | NOVARTIS AG (CH) | 2012-10-16 | — | — | US | claimed |
| US-20110251205-A1 | SQUARAMIDE DERIVATIVES AS CXCR2 ANTAGONIST | NOVARTIS AG | 2011-10-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251205-A1 | SQUARAMIDE DERIVATIVES AS CXCR2 ANTAGONIST | CXCR2, CXCR3, CXCR1 | CCR6 57/4885CXCR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.