Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24118803 | 0.84 | MEN1 (0.62) | MEN1KMT2ATP53HDAC2HDAC8 | |
| SCHEMBL31219284 | 0.80 | HTT (0.62) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL25160333 | 0.80 | F2 (0.49) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL3190254 | 0.78 | MEN1 (0.68) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL22531833 | 0.77 | TP53 (0.71) | F2PLGPLAUKLKB1PRSS1 | |
| SCHEMBL19332610 | 0.76 | TUBB4A (0.43) | HDAC2HDAC8HDAC6 | |
| SCHEMBL30300320 | 0.76 | POLB (0.42) | MEN1KMT2A | |
| SCHEMBL5222297 | 0.76 | POLB (0.42) | MEN1KMT2A | |
| SCHEMBL2911616 | 0.75 | HDAC2 (0.71) | PLAUMEN1KMT2ACASP3SENP8 | |
| SCHEMBL3827286 | 0.74 | HDAC1 (0.72) | MEN1KMT2ATP53CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023061263-A1 | SHP2 INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | 北京泰德制药股份有限公司 | 2023-04-20 | — | — | WO | disclosed |