Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20644563 | 1.00 | MAPT (0.37) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL25160125 | 0.87 | MAPT (0.37) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20644511 | 0.84 | MAPT (0.33) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20652848 | 0.83 | MAPT (0.50) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20644496 | 0.83 | MAPT (0.50) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20644408 | 0.81 | MAPT (0.31) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20644605 | 0.81 | KDM4E (0.31) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20644514 | 0.81 | ACACB (0.32) | LMNASMN1; SMN2EGLN1ACACB | |
| SCHEMBL20644439 | 0.79 | PRMT5 (0.37) | DGAT1 | |
| SCHEMBL20644543 | 0.78 | ABCB11 (0.35) | MAPTLMNASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3397629-B1 | METALLOENZYME INHIBITOR COMPOUNDS | NQP 1598 LTD (KY) | 2023-04-19 | — | — | EP | disclosed |