Phenadoxone

Phenadoxone

SCHEMBL25165

CCC(=O)C(CC(C)N1CCOCC1)(c1ccccc1)c1ccccc1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 4/20 0.63
OPRD1 P41143 2/20 0.63
GRIN2D O15399 2/20 0.54
GRIN1 Q05586 2/20 0.54
GRIN2A Q12879 2/20 0.54
GRIN2B Q13224 2/20 0.54
GRIN2C Q14957 2/20 0.54
DRD3 P35462 2/20 0.54
CACNA1F O60840 1/20 0.54
ABCB1 P08183 1/20 0.54
CYP2B6 P20813 1/20 0.54
DRD4 P21917 1/20 0.54
OPRK1 P41145 1/20 0.54
CACNA1D Q01668 1/20 0.54
KCNH2 Q12809 1/20 0.54
CACNA1S Q13698 1/20 0.54
CACNA1C Q13936 1/20 0.54
MRGPRX2 Q96LB1 1/20 0.54
KCNA5 P22460 2/20 0.48
DRD2 P14416 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenadoxone SCHEMBL2032631 0.99 OPRM1 (0.62) OPRM1OPRD1GRIN2DGRIN1GRIN2A
Phenadoxone SCHEMBL9858401 0.96 OPRM1 (0.59) OPRM1OPRD1GRIN2DGRIN1GRIN2A
Phenadoxone SCHEMBL11319633 0.94 OPRM1 (0.57) OPRM1OPRD1GRIN2DGRIN1GRIN2A
Dipipanone SCHEMBL25367 0.87 OPRM1 (0.57) OPRM1OPRD1GRIN2DGRIN1GRIN2A
Dipipanone SCHEMBL392119 0.86 OPRM1 (0.56) OPRM1OPRD1GRIN2DGRIN1GRIN2A
Phenadoxone SCHEMBL6912655 0.83 TSHR (0.48) OPRM1OPRD1SMN1; SMN2ALDH1A1TSHR
Dextromoramide SCHEMBL29395675 0.82 SMN1; SMN2 (0.51) OPRM1OPRD1KCNA5SMN1; SMN2CYP3A4
SCHEMBL9917093 0.81 OPRM1 (0.50) OPRM1OPRD1GRIN2DGRIN1GRIN2A
Dextromoramide SCHEMBL29581857 0.78 SMN1; SMN2 (0.46) OPRM1OPRD1KCNA5SMN1; SMN2CYP3A4
SCHEMBL9917096 0.74 SLC6A2 (0.43) OPRM1OPRD1GRIN2DGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6678 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-20250319074-A1 TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME UNIV EAST CAROLINA (US) 2025-10-16 US claimed
US-12383743-B2 Treatment of addiction and dependency TACA JR ARTURO C (US) 2025-08-12 US claimed
US-20250228771-A1 ALKALINE INTRAORAL PRODUCTS EMPLICURE AB (publ) (SE) 2025-07-17 US claimed
EP-4581017-A1 NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS Biodol Therapeutics (FR) 2025-07-09 EP claimed
EP-4565202-A1 ALKALINE INTRAORAL PRODUCTS EMPLICURE AB (publ) (SE) 2025-06-11 EP claimed
WO-2024254056-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF CATALENT ONTARIO LIMITED (CA) 2024-12-12 WO claimed
US-12133922-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2024-11-05 US claimed
US-20240288374-A1 PLASMONIC NANOPARTICLE PLATFORM FOR ANALYTE DETECTION Zymeron Corporation 2024-08-29 US claimed
WO-2024172892-A1 PLASMONIC NANOPARTICLE PLATFORM FOR ANALYTE DETECTION Zymeron Corporation (US) 2024-08-22 WO claimed
EP-0785775-A1 MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS Euroceltique S.A. (LU) 1997-07-30 EP claimed
EP-0731694-A4 1996-10-02 EP claimed
EP-0731694-A1 OPIOID FORMULATIONS FOR TREATING PAIN Euroceltique S.A. (LU) 1996-09-18 EP claimed
CN-1130352-A Method for relieving pain by orally administering 24-hour sustained-release opioid dosage form capable of rapidly increasing initial blood concentration of patient EURO CELTIQUE SA (LU) 1996-09-04 CN claimed
WO-1996014058-A1 MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS EURO-CELTIQUE, S.A. (LU) 1996-05-17 WO claimed
WO-1995014460-A1 OPIOID FORMULATIONS FOR TREATING PAIN EURO-CELTIQUE S.A. (LU) 1995-06-01 WO claimed
EP-0647448-A1 Orally administrable opioid formulations having extended duration of effect Euroceltique S.A. (LU) 1995-04-12 EP claimed
EP-0608893-A1 Inhibiting the development of tolerance to and/or dependence on an additive substance VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-08-03 EP claimed
EP-0415693-A1 Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence ARIZONA TECHNOLOGY DEVELOPMENT CORPORATION (US) 1991-03-06 EP claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed