Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30329704 | 1.00 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL30329752 | 0.90 | ABCB1 (0.40) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL30329812 | 0.82 | HAVCR2 (0.43) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL25166581 | 0.82 | HAVCR2 (0.43) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL30330226 | 0.78 | EPHB4 (0.35) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL25166694 | 0.78 | EPHB4 (0.35) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL30330007 | 0.75 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL30330176 | 0.75 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL25166186 | 0.74 | EHMT2 (0.51) | NPC1RAB9ASMN1; SMN2KMT2AKCNH2 | |
| SCHEMBL30330220 | 0.74 | EHMT2 (0.51) | NPC1RAB9ASMN1; SMN2KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |